1171 patients
Enrolled biopsy patients (live sync)
Taipei Renal Transcriptomics and Outcomes Investigation
Precision Medicine in Nephrology: Understanding the Kidney's Molecular Landscape
TRTOI is a prospective cohort established at Taipei Veterans General Hospital in 2018, integrating kidney biopsy transcriptomics, proteomics, digital pathology, and longitudinal clinical follow-up to create Taiwan's largest kidney biomedical database.
~20000
Kidney genes
150 /yr
Annual participant enrollment target
8 yr+
Long-term clinical outcome follow-up
Multi-Omics Platform
Kidney Biopsy Provides a Comprehensive View of Kidney Disease
Renal function tests (eGFR, proteinuria) often fail to reflect true tissue injury. TRTOI is tissue-based, integrating multi-layered omics data to uncover the molecular mechanisms driving kidney disease progression.
Whole-genome sequencing
Whole-genome sequencing (WGS) identifies single-nucleotide variants (SNVs), indels, structural variants, and copy-number alterations to characterize the genomic landscape of kidney disease.
Transcriptomics
Kidney biopsy samples undergo RNA sequencing following microdissection to quantify ~ 20,000 genes and identify key transcription factors and disease-associated pathways.
Proteomics
Blood and urine proteins are analyzed using the Olink® PEA platform to identify non-invasive biomarkers for kidney disease.
Digital pathology
Quantification of fibrosis (IFTA) and glomerular lesions with AI-assisted image analysis, linking tissue to molecular profiles.
Clinical big data
Structured electronic health records linked to ultrasound imaging and longitudinal clinical outcomes.
Cohort Snapshot
TRTOI Cohort Overview
Diabetes
Sex
CKD stage
Partner to advance precision nephrology
Whether you are a clinician, researcher or industry partner, you are welcome to join the TRTOI collaborative network.
Contact us →